Prof Justus Apffelstaedt and Associates is an active participating centre in multicentre clinical trials that have defined breast cancer treatment in the past and will define breast cancer treatment in the future.

Members of the team of Prof Justus Apffelstaedt and Associates participated, amongst others, in the ATAC, BIG-I-98, FASLODEX, LETROZOLE and SABRE trials.

LINKS TO PUBLICATIONS Apffelstaedt JP, Steenkamp V, Baatjes K. S Afr Med J. 2008 Dec;98(12):950-3.PMID: 19374072 [PubMed - indexed for MEDLINE Performance data of screening mammography at a dedicated breast health centre Shyyan R, Sener SF, Anderson BO, Fernández Garrote LM, Hortobágyi GN, Ibarra JA Jr, Ljung BM, Sancho-Garnier H, Stalsberg H; on behalf of the Breast Health Global Initiative Diagnosis Panel The Breast Health Global Initiative Diagnosis Panel members included Gaurav Agarwal; Justus Apffelstaedt; Nuran S. Bese; Maira Caleffi; R. F. Chinoy; Kathleen Errico; Leticia María Fernández Garrote; Gabriel N. Hortobagyi; Julio A. Ibarra, Jr.; Kardinah Britt-Marie Ljung; Mandar Nadkarni; Anthony Nsiah-Asare; Mary Onyango; Hélène Sancho-Garnier; Stephen F. Sener (Co-chair); Roman Shyyan (Co-chair); and László Vass.. Guideline implementation for breast healthcare in low- and middle-income countries : diagnosis resource allocation. Cancer. 2008 Oct 3;113(S8):2257-2268. [Epub ahead of print] PMID: 18837018 [PubMed - as supplied by publisher] Mohamad HB, Apffelstaedt JP. Counseling for male BRCA mutation carriers - a review. Breast. 2008 Oct;17(5):441-50. Epub 2008 Jul 26. PMID: 18657973 [PubMed - in process] Wasserman LJ, Apffelstaedt JP, Odendaal Jde V. Conservative management of breast cancer in the elderly in a developing country. World J Surg Oncol. 2007 Oct 1;5:108. PMID: 17908323 [PubMed - indexed for MEDLINE] Tripathy D, Lichinitzer M, Lazarev A, MacLachlan SA, Apffelstaedt J, Budde M, Bergstrom B; MF 4434 Study Group. Oral ibandronate for the treatment of metastatic bone disease in breast cancer: efficacy and safety results from a randomized, double-blind, placebo-controlled trial. Ann Oncol. 2004 May;15(5):743-50. PMID: 15111341 [PubMed - indexed for MEDLINE] Rosen LS, Gordon D, Kaminski M, Howell A, Belch A, Mackey J, Apffelstaedt J, Hussein MA, Coleman RE, Reitsma DJ, Chen BL, Seaman JJ. Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trial. Cancer. 2003 Oct 15;98(8):1735-44. PMID: 14534891 [PubMed - indexed for MEDLINE] Apffelstaedt JP. Locally advanced breast cancer in developing countries: the place of surgery. World J Surg. 2003 Aug;27(8):917-20. Epub 2003 Jun 6. Review. PMID: 12784145 [PubMed - indexed for MEDLINE] Mouridsen H, Gershanovich M, Sun Y, Perez-Carrion R, Boni C, Monnier A, Apffelstaedt J, Smith R, Sleeboom HP, Jaenicke F, Pluzanska A, Dank M, Becquart D, Bapsy PP, Salminen E, Snyder R, Chaudri-Ross H, Lang R, Wyld P, Bhatnagar A. Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group. J Clin Oncol. 2003 Jun 1;21(11):2101-9. PMID: 12775735 [PubMed - indexed for MEDLINE] Odendaal Jde V, Apffelstaedt JP. Limited surgery and tamoxifen in the treatment of elderly breast cancer patients. World J Surg. 2003 Feb;27(2):125-9. PMID: 12616422 [PubMed - indexed for MEDLINE] Sandelin K, Apffelstaedt JP, Abdullah H, Murray EM, Ajuluchuku EU. Breast Surgery International--breast cancer in developing countries. Scand J Surg. 2002;91(3):222-6. Review. PMID: 12449462 [PubMed - indexed for MEDLINE] Apffelstaedt J. Indications and complications of latissimus dorsi myocutaneous flaps in oncologic breast surgery. World J Surg. 2002 Sep;26(9):1088-93. Epub 2002 Jun 21. PMID: 12209237 [PubMed - indexed for MEDLINE] Rosen LS, Gordon D, Kaminski M, Howell A, Belch A, Mackey J, Apffelstaedt J, Hussein M, Coleman RE, Reitsma DJ, Seaman JJ, Chen BL, Ambros Y. Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trial. Cancer J. 2001 Sep-Oct;7(5):377-87. PMID: 11693896 [PubMed - indexed for MEDLINE] Mouridsen H, Gershanovich M, Sun Y, Pérez-Carrión R, Boni C, Monnier A, Apffelstaedt J, Smith R, Sleeboom HP, Jänicke F, Pluzanska A, Dank M, Becquart D, Bapsy PP, Salminen E, Snyder R, Lassus M, Verbeek JA, Staffler B, Chaudri-Ross HA, Dugan M. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol. 2001 May 15;19(10):2596-606. Erratum in: J Clin Oncol 2001 Jul 1;19(13):3302. PMID: 11352951 [PubMed - indexed for MEDLINE] Voss M, Schneider JW, Apffelstaedt J. Axillary lymph node involvement in stage III breast cancer: treatment implications. J Surg Oncol. 1999 Jul;71(3):162-6. PMID: 10404132 [PubMed - indexed for MEDLINE] Swanepoel E, Apffelstaedt JP. Malignant pericardial effusion in breast cancer: terminal event or treatable complication? J Surg Oncol. 1997 Apr;64(4):308-11. PMID: 9142188 [PubMed - indexed for MEDLINE] Apffelstaedt JP, Driscoll DL, Spellman JE, Velez AF, Gibbs JF, Karakousis CP. Complications and outcome of external hemipelvectomy in the management of pelvic tumors. Ann Surg Oncol. 1996 May;3(3):304-9. PMID: 8726187 [PubMed - indexed for MEDLINE] Apffelstaedt JP, Zhang PJ, Driscoll DL, Karakousis CP. Various types of hemipelvectomy for soft tissue sarcomas: complications, survival and prognostic factors. Surg Oncol. 1995 Aug;4(4):217-22. PMID: 8528484 [PubMed - indexed for MEDLINE] Apffelstaedt JP, Driscoll DL, Karakousis CP. Partial and complete internal hemipelvectomy: complications and long-term follow-up. J Am Coll Surg. 1995 Jul;181(1):43-8. PMID: 7599770 [PubMed - indexed for MEDLINE] Apffelstaedt JP, Van Zyl JA, Muller AG. Breast cancer complicated by pleural effusion: patient characteristics and results of surgical management. J Surg Oncol. 1995 Mar;58(3):173-5. Review. PMID: 7898113 [PubMed - indexed for MEDLINE] Apffelstaedt JP, Müller R. Results of mandatory exploration for penetrating neck trauma. World J Surg. 1994 Nov-Dec;18(6):917-9; discussion 920. PMID: 7846919 [PubMed - indexed for MEDLINE]